![]() Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Evolution of the aging brain transcriptome and synaptic regulation. The cell-non-autonomous nature of electron transport chain-mediated longevity. DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study. A mammalian methylation array for profiling methylation levels at conserved sequences. Universal DNA methylation age across mammalian tissues. A multi-tissue full lifespan epigenetic clock for mice. Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions. Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life. Physiological migration of hematopoietic stem and progenitor cells. Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity. Preclinical assessment of young blood plasma for Alzheimer disease. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Rejuvenation of regeneration in the aging central nervous system. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin. Experimental prolongation of the life span. Parabiosis as a method for studying factors which affect aging in rats. Profiling epigenetic age in single cells. Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging. Kerepesi, C., Zhang, B., Lee, S.-G., Trapp, A. Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells. Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Reprogramming to recover youthful epigenetic information and restore vision. Reversing age: dual species measurement of epigenetic age with a single clock. Reversal of epigenetic aging and immunosenescent trends in humans. Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity. Using DNA methylation profiling to evaluate biological age and longevity interventions. A whole lifespan mouse multi-tissue DNA methylation clock. DNA methylation age of human tissues and cell types. Hallmarks of aging: an expanding universe. Alive and well? Exploring disease by studying lifespan. Altogether, we reveal that long-term HPB results in lasting epigenetic and transcriptome remodeling, culminating in the extension of lifespan and healthspan.īrett, J. In addition, old HPB mice showed gene expression changes opposite to aging but akin to several lifespan-extending interventions. Transcriptomic and epigenomic profiles of anastomosed mice showed an intermediate phenotype between old and young, suggesting a global multi-omic rejuvenation effect. Remarkably, this rejuvenation effect persisted even after 2 months of detachment. HPB drastically reduced the epigenetic age of blood and liver based on several clock models using two independent platforms. Old detached mice exhibited improved physiological parameters and lived longer than control isochronic mice. Here we performed extended (3-month) HPB, followed by a 2-month detachment period of anastomosed pairs. However, its impact on biological age and long-term health is unknown. Heterochronic parabiosis (HPB) is known for its functional rejuvenation effects across several mouse tissues.
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